On September 30, 2021 the CHAIMELEON consortium met online for their semi-annual meeting. The project progress and first results regarding the foundations for the design and set-up of the CHAIMELEON repository on a technical, clinical, ethical, and legal level were presented. The partners moreover discussed the next steps for the upcoming months for the set-up and start of the population of the CHAIMELEON repository, efforts in data harmonisation as well as integrity and interpretability of AI modesl, measures to ensure long-term sustainability of the repository, and related dissemination and exploitation actions.